For nearly a year now, we have suffered the devastating effects of COVID-19—an invisible enemy that has taken lives, shuttered businesses and turned our world upside down. Putting an end to this nightmare depends on the efficient distribution of COVID-19 vaccines. As New York State continues to roll out its vaccination plan, a number of questions remain. What can be done to inoculate people more quickly? When will those with underlying conditions be able to access the vaccine? In addition, perhaps most importantly, how does the vaccination rate correlate with the reopening of our state? These, along with many other questions, need to be answered to ensure we get New York back on track as quickly as possible.